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EPISODE 757  |  
December 2, 2025
In this episode, Zain Asgar, co-founder and CEO of Gimlet Labs, joins us to discuss the heterogeneous AI inference across diverse hardware. Zain argues that the current industry standard of running all AI workloads on high-end GPUs is unsustainable for agents, which consume significantly more tokens than traditional LLM applications. We explore Gimlet’s approach to heterogeneous inference, which involves disaggregating workloads across a mix of hardware—from H100s to older GPUs and CPUs—to optimize unit economics without sacrificing performance. We dive into their "three-layer cake" architecture: workload disaggregation, a compilation layer that maps models to specific hardware targets, and a novel system that uses LLMs to autonomously rewrite and optimize compute kernels. Finally, we discuss the complexities of networking in heterogeneous environments, the trade-offs between numerical precision and application accuracy, and the future of hardware-aware scheduling.
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Retrieval-augmented generation promised to bring ChatGPT’s magic to enterprise data. But while organizations rushed to build chatbots, they often struggled to deliver real business value. This comprehensive guide reveals RAG’s full potential beyond conversational interfaces.

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